Eran Segal is a computational biologist who tested some theories about the best way for humans to eat. In the end he determined that there is no one best way for everyone to eat. What he learned in the process can add more depth to why the calorie model fails, what foods and ways of eating impact blood glucose and thus fat storage, and the role of gut bacteria.
You can find out more about his work through the Weizmann Institute of Science.